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Our study entitled "Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age" has been published in Nature Metabolism. This has been an incredibly exciting collaboration with excellent national and international colleagues in the fields of aging, neuroscience, tumor and bone biology, infectiology, visceral surgery and immunology. We thank and congratulate the lead author Dr. Daniel Brigger from our Lab and all other contributors for this exceptional piece of work! The study has been co-led by Dr. Mario Noti (formerly: Institute of Pathology at the University of Bern; currently: Department of Gastrointestinal Health, Immunology, Nestlé Research) and funded by the VELUX STIFTUNG, the FONDATION ACTERIA as well as the FreeNovation and biological-medical research programs from Novartis. 

We also thank Prof. Chih-Hao Lee from Harvard University for highlighting this study in an additional News and Views article!

- Report from the local TV broadcasting station TeleBärn.

 
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We are happy, pround and honoured to announce that PD Dr. Alexander Eggel has been awarded the Swiss Immunology Early Career Award 2020 (SIECA 2020) by the Swiss Society of Allergology and Immunology (SGAI) for his outstanding scientific achievements. The prize has been sponsored by Sanofi Genzyme Switzerland.

 
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Our PhD student Pascal Guntern has published a review article on the "Past, present aund future of anti-IgE biologics" in the European Journal of Allergy and Clinical Immunology. Dive into the history of the Omalizumab antibody or take a glimps at the potential of alternative scaffold based drug candidates! Congrats on the nice summary, Pascal!

 
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In an exciting collaboration with our colleagues from the group of Prof. Theodore Jardetzky (Stanford University), we have published findings detailling the modes-of-action of the novel therapeutic anti-IgE antibody Ligelizumab in Nature Communications. Congratulations to both first authors, Pascal and Svetlana and to everyone involved in the study. The article is open access - so, feel free to check it out!

 
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Alex has had the pleasure to support the people from the Berner Generationenhaus to organize an exhibition focusing on the topic "Forever Young - Willkommen im langen Leben", in which they highlight various interesting aspects of the aging process. They do this in a very entertaining but also informative manner. We highly recommend a visit of the exhibition! It's open until March 29, 2020. Here, you'll get more information about the opening hours and entry fees: https://begh.ch/ausstellung

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Prof. Gomez from the University of South Carolina School of Medicine has published a rewiew article about "Current Strategies to Inhibit High Affinity FcεRI-Mediated Signaling for the Treatment of Allergic Disease" in Frontiers in Immunology featuring a lot of our work. Take a look this nice summary.

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Current Opinion in Immunology has published a special issue on allergy and hypersensitivity. Together with Prof. Onur Boyman and Dr. Mario Noti, Alex served as editor of this issue. We are grateful to all the authors, who helped to put this update on allergy and hypersensitivity together. Enjoy reading!

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We are happy that the US National Institutes of Health has decided to support our research! In this R01 funded project, we will explore the suppression of basophil activation by different IgE glycovariants together with the structural biology group of Prof. Theodore Jardetzky from Stanford University

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We have recently published an informative article about different approaches to target IgE in allergic disorders in the journal Current Opinion in ImmunologyOur contribution will be part of a special issue on allergy and hypersensitivity that will be released in October 2018 and has been edited by Onur Boyman, Mario Noti and ourselves.

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Our former PhD students Dr. Fabian Zellweger and Dr. Patrick Buschor have recently published an article about the role of monomeric IgE in the regulation of the IgE receptor expression and cell survival in human primary basophils in the Springer Nature Journal Cell Death and DiseaseWe thank and congratulate all contributors!

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We are very happy to announce that the Velux Stiftung has decided to support our research on healthy aging. As stated on their website: "The foundation aims to have an impact on and contribute to sustainable improvement and the benefit of society. This is achieved by supporting the creation of new knowledge through cutting-edge research and the fostering of its application and dissemination. The foundation attains leverage by focusing on projects with a high potential to initiate change and impact." Our lab is dedicated to contribute to the achievment of these aims and highly appreciates the support of the foundation! 

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mapUniversity of Bern, Sahlihaus 2
CH-3010 Bern 

map+41 (0)31 632 22 87